Psilocybin: decreased activity, increased connections

Study Finds That Psilocybin Creates A Hyperconnected Brain

In a past study, it was concluded that psilocybin decreased brain activity resulting in a sort of dreamlike state, but further research has found this to be only a partial explanation.

A more recent study, conducted at King's College London, has found that psilocybin does seem to disrupt normal communication networks in the brain, hence the decreased activity. However, fMRI scans showed that, while some of the brain decreased in activity, the psilocybin somehow connected "brain regions that don't normally talk together," said Paul Expert, study co-author and physicist at King's College London.